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Regional differences in epidermal thickness and behavioral response following partial denervation of the rat paw

In order to investigate the relation between changes in epidermal thickness and pain-related behavior in different rat hind paw areas we performed partial denervation using two experimental models of neuropathic pain injury: spinal nerve ligation (SNL) and chronic constriction injury (CCI). Denervation produced significant epidermal thinning in both models. The most pronounced thinning was observed in the lateral paw region of the SNL group. Both models showed increase in hyperalgesic response during the postoperative period and no behavioral differences between testing regions. Our study showed that partial denervation induces regional differences in epidermal thinning but not in pain-related behavior.

spinal nerve ligation; chronic constriction injury; neuropathic pain; partial denervation; skin; epidermal thinning; hyperalgesia

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