Cellular immunity status of children with beta-thalassemia (CROSBI ID 472466)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa
Podaci o odgovornosti
Nakić, Melita ; Batinić, Drago ; Boranić, Milivoj ; Goreta, Nada ; Rudolf, Maja
engleski
Cellular immunity status of children with beta-thalassemia
Thalassemic syndromes obtain in Croatian population, predominantly in the Mediterranean region. We have recently seen three examples of thalassemia minor and used the opportunity to acquire information about the immunostatus since the genetic defect of hemoglobin synthesis and/or the increased turnover of erythrocytes and iron overload might be accompanied by alterations of the immune competence (Bayoumi RAL, Med Hypoth 48:11, 1997 ; Lombardi G et al, Haematologica 79:406, 1994). Essential laboratory data are given in the tables. As seen, the response to PHA was reduced, indicating an impairment of T-cell immunity. The responses to the B-cell mitogens ConA and PWM were normal and the main lymphocyte subpopulations were within the normal range.Diminished T-cell respose may indicate an impairment of cellular immunity due to the defect itself (as postulated) but may also be attributed to viral infections that frequently occur in children with thalassemic syndromes. The immune status of thalassemic patients may be of interest in view of vaccination against HBV (Leonardi S et al, Arch Dis Child 65:527, 1990).
thalassemia; cellular immunorectivity
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Podaci o prilogu
81-81-x.
1999.
objavljeno
Podaci o matičnoj publikaciji
Pediatric Research 45/5
Lister, George
Baltimore (MD): Lippincott Williams and Wilkins
Podaci o skupu
XVII. Scientific Congress of the European Society for Pediatric Hematology and Immunology
poster
13.05.1999-15.05.1999
Washington D.C., Sjedinjene Američke Države