Identification of a novel HPV 16 E1 gene variant (CROSBI ID 543024)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Sabol, Ivan ; Matovina, Mihaela ; Grce, Magdalena
engleski
Identification of a novel HPV 16 E1 gene variant
The Human papillomavirus (HPV) 16 genome has been extensively studied, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical specimens, 11.2% were found to contain 63-nucleotides duplication in this region. Sequence analysis of the E6 and the E7 regions has shown that all samples containing this duplication were related to E6-G350 variant of the HPV 16. In silico translation of the E1 gene with the duplication has shown that the protein has extra 21 amino acids as the duplication is “ in frame” and does not introduce a premature stop codon. The affected region has currently no significant function ascribed to it. However, comparison of cervical lesion severity of the examinees having normal or variant E1 genes has shown that the variant group is significantly (Fischers exact test, P=0.0401) less associated to high grade cervical lesions, suggesting that this particular duplication might reduce the oncogenic potential of HPV 16, and also might clarify the differences of E6-G350 variant oncogenicity observed in European populations. Further research is needed to elucidate the biology of these HPV 16 E1 variants and the biological effect of this particular duplication.
Human papillomavirus type 16 variant
Istovremeno i poster prezentacija
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
9-9.
2008.
objavljeno
Podaci o matičnoj publikaciji
Program & Abstract Book of the 5th International HPV & Skin Cancer Conference, Heidelberg, Germany, 22-24 October 2008
Gissmann, Lutz ; Nindle, Ingo ; Rosl, Frank
Heidelberg: DKFZ
Podaci o skupu
Human papillomavirus and cancer. 5th International HPV & Skin Cancer Conference, Heidelberg, Germany, 22-24 October 2008
pozvano predavanje
22.10.2008-24.10.2008
Heidelberg, Njemačka