A Multiphysics Model for Studying the Influence of Pulse Repetition Frequency on Tissue Heating During Electrochemotherapy (CROSBI ID 543831)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lacković, Igor ; Magjarević, Ratko ; Miklavčič, Damjan
engleski
A Multiphysics Model for Studying the Influence of Pulse Repetition Frequency on Tissue Heating During Electrochemotherapy
For enhancing the delivery of chemotherapeutic drugs to cancer cells or for the delivery of foreign genes, cells can be exposed to strong external electric field, known to induce membrane electroporation. The use of electroporation for delivery of chemotherapy (electrochemotherapy) involves the injection of chemotherapeutic agent followed by a local delivery of a train of short high voltage pulses to the tumor nodule (i.e. 8 square-wave pulses of 100 μ s delivered at the repetition frequency of 1 Hz, with a voltage-to-distance ratio of up to 1500 V/cm). As biological tissues are conductive, an electrical current is flowing during pulse delivery and Joule heating is also taking place. Recent experimental studies have shown that using higher repetition frequency (e.g. 1 kHz or 5 kHz) have beneficial effects for patients (better tolerance due to a single unpleasant contraction instead of a number of individual contractions, shorter treatment time, etc.). In this work we investigated the influence of pulse repetition frequency on tissue heating. We developed a multiphysics model that couples PDEs for electric and thermal field calculation. Realistic electrode geometries (plate electrodes ; needle electrodes) and tissue electrical and thermal properties were used. All simulations were performed with COMSOL Multiphysics. Results of our simulations show that the increase of pulse repetition frequency from 1 Hz to 1 kHz causes higher temperature rise in the tissue due to the Joule heating. However, the increase of bulk tissue temperature is still low and unlikely to induce thermal damage.
electroporation; electrochemotherapy; Joule heating; multiphysics model; finite-element method
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Podaci o prilogu
2609-2613.
2008.
objavljeno
Podaci o matičnoj publikaciji
Vander Sloten ; Verdonck ; Nyssen ; Haueisen
Antverpen: Springer
978-3-540-89207-6
1680-0737
Podaci o skupu
4th European Congress for Medical and Biological Engineering 2008
predavanje
23.11.2008-27.11.2008
Antwerpen, Belgija