engleski

IS HIGH CHOLESTEROL LEVEL A RISK FACTOR FOR ALZHEIMER DISEASE?

The aim of this study was to evaluate HDL, LDL and total cholesterol serum levels in patients with AD and VaD. 111 (n=111) patients with diagnosis of dementia were included in this study. AD was diagnosed in 64 patients and VaD in 47 patients We have analysed the level of total, LDL and HDL cholesterol in all patients. In the group of patients with diagnosed Alzheimer's dementia , 24 patients had cholesterol values within normal range, while 40 patients had elevated levels of cholesterol. Mean value of total plasma cholesterol in this group was 5, 53(SD=1.2) with LDL plasma cholesterol of 3, 64 (SD=0.91), and HDL plasma cholesterol of 1, 39 (SD=0.34). In the group of patients with diagnosed vascular dementia, 21 patients had cholesterol values within normal range, while 26 patients had elevated levels of cholesterol. In this group, mean value of total plasma cholesterol was 5, 9 (SD=1.04), plasma HDL cholesterol value of 1, 44 (SD=0, 57) and LDL cholesterol value of 3, 7 (SD=0, 88). Total cholesterol, LDL cholesterol and HDL cholesterol levels are higher in the group with vascular dementia but the difference is not statisticaly significant. Our results indicate that total and LDL cholesterol levels are risk factors for both type of dementia, although slightly more pronounced in patients with vascular dementia

cholesterol; dementia; Alzheimer's dementia

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