engleski

BREATH HOLDINH INDEX AND EVALUATION OF COGNITIVE DECLINE

Background: The aim of the study was to evaluate role of breath holding index (BHI) in recognizing patients who are at risk for developing cognitive imparement of vascular type. Patients and methods: We included 20 volunteers who were examined at our Neurology Department. They were divided into 2 groups, in first group were healthy volunteers at age 35-45 and in the second group were volunteers at age 65-75. In first group we selected patients with BHI values 1, 7&plusmn ; 2 and in the second group with values 1, 1&plusmn ; 0, 5. Mini mental State Exam (MMSE) and Montreal Cognitive Assesment (MoCA) were performed as well as standard laboratory workup, CT scan, Color Doppler and Power Doppler of the main head and neck vessels and Transcranial Doppler. We excluded individuals with severe carotid stenosis. Results: We excluded recent ischemic lesions in our population (CT scan), there was no statisticaly significant difference in conventional risk factors and gender between two groups. There was statisticaly significant difference between two groups in MoCA (29&plusmn ; 1 vrs 24&plusmn ; 1), no statistically significant difference was found in MMSE (29&plusmn ; 1 vrs 28&plusmn ; 1). Conclusion: These results show that impared cerebrovascular reactivity (decline in BHI) can be predictor of cognitive decline as a result of microvessel disfunction.

breath holding index; cognitive decline

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