New bispyridinium oximes : In vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning (CROSBI ID 146375)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Berend, Suzana ; Lucić Vrdoljak, Ana ; Radić, Božica ; Kuča, Kamil
engleski
New bispyridinium oximes : In vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning
Improving the efficacy of antidotal treatment of poisonings with nerve agents is still a challenge for the scientific community. This study investigated the interactions of four bispyridinium oximes with human erythrocyte acetylcholinesterase (AChE) and their effects on soman- and tabun-poisoned mice. Oximes HI-6 and TMB-4 were used for comparison. These oximes inhibited AchE with inhibitory potency (IC50) ranging from 0.02 to 1.0 mM. The best reactivating potency (%R) was obtained with K074, when AChE was inhibited by tabun. The protective potency (P50) of all oximes in human erythrocyte AChE inhibited by soman and tabun could not be determined. In tabun-poisoned mice very good antidotal efficacy was obtained with K027, K048, and K074, which makes them interesting for future investigation. The combination of HI-6 and atropine is the therapy of choice for soman poisoning.
acetylcholinesterase; Soman; Tabun; oxime; antidotal efficacy
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Podaci o izdanju
175 (1/3 (S1))
2008.
413-416
objavljeno
0009-2797
10.1016/j.cbi.2008.04.031
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti