Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids (CROSBI ID 147452)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Jones, Michael ; Mercer, Amy E. ; Stocks, Paul A. ; La Pensée, Louise J. I. ; Cosstick, Rick ; Park, B. Kevin ; Kennedy, Miriam E. ; Piantanida, Ivo ; Ward, Stephen A. ; Davies, Jill ; Bray, Patrick G. ; Rawe, Sarah L. ; Baird, Jonathan ; Charidza, Tafadzwa ; Janneh, Omar ; Stocks, Paul A. ; O’ Neill, Paul M.
engleski
Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2 to 4 fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle.
Artemisinin ; acridine ; antimalarial ; anticancer ; apoptosis ; DNA ; confocal microscopy
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Podaci o izdanju
19 (7)
2009.
2033-2037
objavljeno
0960-894X
1464-3405
10.1016/j.bmcl.2009.02.028
Povezanost rada
Kemija, Temeljne medicinske znanosti
