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Iron absorption from ferro-sulphate and ferro-serinate in the swine's caecum

In the bags made from swine's caecum the absorption of iron from the simple ferro(II)-sulphate and ferro(II)-serinate solutions was investigated. In bags, i.e. from the epithelial side of the epithelium, the solution of either ferro(II)-sulphate or ferro(II)-serinate solution containing 1, 3, 5, 7 and 10 mg/100 mL of iron, respectively, was introduced, while Tyrode solution was usually placed outside the bag, i.e. from the submucosal side of the ceacum epithelium. After the experiments having lasted 3 hours at room temperature, the iron concentration in the solution outside of the bag (i.e. from the submucosal side of the ceacum epithelium) was determined. At the end of the experiments with the froo(II)-sulphate solution as the test solution the iron concentration in the solution outside the bags amounted to 8.06 &plusmn ; 0.95, 8.92 &plusmn ; 1.04, 7.84 &plusmn ; 1.25, 10.58 &plusmn ; 0.61 and 16.5 &plusmn ; 1.78 μ g/100 mL, respectively, and from the testsolution containing ferro(II)-serinate amounted to 3.56 &plusmn ; 0.40, 7.34 &plusmn ; 0.61, 10.99 &plusmn ; 0.54, 13.62 &plusmn ; 0.84 and 25.93 &plusmn ; 1.44 μ g/100 mL, respectively. It seems that the iron from such inorganic salts as ferro(II)-sulphate was absorbed preferentially by the saturable process, probably coupled with the intacellular iron transport mechanisms, while the iron chelated as ferro(II)-serinate was absorbed by the passive transport depending on the concentration gradient and the solubility of the particular chelate in the intraepithelial compartmaents of the swine caecum epithelium.

iron absorption; caecum epithelium; swine

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