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Pregled bibliografske jedinice broj: 38177

Časopis

Autori: Lasn, Helen; Šimić, Goran; Winblad, Bengt; Bogdanović, Nenad
Naslov: Oligodendroglial cells in the hippocampal formation in aging and Alzheimer's disease
Izvornik: Neurobiology of aging (0197-4580) 19 (1998), suppl. 4; 236-236
Vrsta rada: kongresno priopćenje
Ključne riječi: Alzheimer's disease; oligodendroglia; hippocampus
Sažetak:
Presence of oligodendroglial cells in the brain is in the close relation to myelination of long projection axons and inhibition of neuritic growth. It was suggested that the pattern of neurofibrillary pathology spreading in Alzheimer's disease resembles the inverse sequence of myelination in the brain (Braak and Braak, 1996). Here we show that in AD brain oligodendroglial cell loss is most pronounced in the hippocampal subfields which undergo extensive neurofibrillary changes during the course of disease. This findings might be in accordance with suggested idea that the lack of oligodendroglial cells and their trophic influence on neurons might lead to destabilization of neuronal cytoskeleton and appearance of neurofibrillary pathology.
Projekt / tema: 108118
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Current Contents Citation Index
Scopus
MEDLINE
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Oligodendroglial cells in the hippocampal formation in aging and Alzheimer's disease



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