Met-enkephalin modulates stress-induced alterations of the immune response in mice (CROSBI ID 78186)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Marotti, Tanja ; Gabrilovac, Jelka ; Rabatić, Sabina ; Smejkal-Jagar, Lidija ; Ročić, Boris ; Haberstock, Helena
engleski
Met-enkephalin modulates stress-induced alterations of the immune response in mice
Overnight restraint stress of mice decreased ConA-driven lymphocyte proliferation, plaque-forming cell response to sheep red blood cells (SRBC), and NK activity in the spleen, but the phagocytic activity was enhanced. Injection of methionine-enkephalin (MENK), 10 mg/kg, IP, 30 min before restraint, abolished these changes (except for the NK activity) and attenuated the stress-induced elevation of glucocorticoids. However, MENK itself affected the immune responses like stress: It decreased NK activity and the PFC response and enhanced phagocytic activity. Contrary to results with stress, MENK had no effect on cell proliferation. The opioid-receptor antagonist naloxone given before restraint reversed the stress-induced enhancement of phagocytosis and the decrease of T-cell proliferation. Alterations of the immune responses induced by restraint stress seem to be mediated by at least two mechanisms: activation of the hypothalamus-pituitary-adrenal (HPA) axis and the secretion of opioid peptides. MENK injected before stress may interfere with either or both mechanisms. T or B lymphocytes seem to be affected by the activation of the HPA axis, and phagocytes by a direct opioid action, whereas NK cells seem to be under the influence of another control mechanism. [References: 46]
met-enkephalin ; stress ; immune response ; naloxone ; hpa axis
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Podaci o izdanju
54 (1)
1996.
277-284
objavljeno
0091-3057
10.1016/0091-3057(95)02112-4
Povezanost rada
Javno zdravstvo i zdravstvena zaštita, Farmacija