Multiplicity and Global Parametric Sensitivity of Structured Biological Models (CROSBI ID 546213)
Prilog sa skupa u zborniku | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Tušek, Ana ; Kurtanjek, Želimir
engleski
Multiplicity and Global Parametric Sensitivity of Structured Biological Models
For a paradigmatic biologically structured model multiplicity and global parameter sensitivity of a chemostat are investigated. The modeling assumptions are bisubstrate growth limitation by carbon and nitrogen sources, presence of two essential intracellular compartments, active protein synthesis system (PSS) and inactive genetic compartment. Variance based global sensitivity of the kinetic parameters is evaluated by the Extended Fourier Amplitude Sensitivity Test (FAST). Computer simulations reveal that multiplicity can be induced by carbon source product synthesis inhibition. Results of the FAST analysis show dominant sensitivity on the maximum specific rate coefficients for assimilation of carbon and synthesis of PSS compartment.
structured chemostat; PSS; multiplicity; FAST sensitivity
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Podaci o prilogu
797-801.
2008.
objavljeno
Podaci o matičnoj publikaciji
Proceedings of the ITI 2008, 30th International Conference on Information Technology Interfaces
Lužar-Stiffler, Vesna ; Hljuz Dobrić, Vesna ; Bekić , Zoran
Zagreb: Sveučilišni računski centar Sveučilišta u Zagrebu (Srce)
978-953-7138-13-4
Podaci o skupu
30th International Conference on Information Technology Interfaces
predavanje
23.06.2008-26.06.2008
Dubrovnik, Hrvatska