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Analysis of HLA antigens in Croatian patients with psoriasis (CROSBI ID 148701)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kaštelan, Marija ; Gruber, Franjo ; Čečuk, Esma ; Kerhin-Brkljačić, Vesna ; Brkljačić-Šurkalović, Ljerka ; Kaštelan, Andrija Analysis of HLA antigens in Croatian patients with psoriasis // Acta dermato-venereologica, 211 (2000), Suppl. 211; 12-13

Podaci o odgovornosti

Kaštelan, Marija ; Gruber, Franjo ; Čečuk, Esma ; Kerhin-Brkljačić, Vesna ; Brkljačić-Šurkalović, Ljerka ; Kaštelan, Andrija

engleski

Analysis of HLA antigens in Croatian patients with psoriasis

In common with most autoimmune diseases, psoriasis is associated with some HLA antigens. We studied the distribution of HLA antigens in Croatian patients with psoriasis: 108 patients were divided into groups according to family history and age of disease onset. HLA antigens were analyzed serologically and HLA-C alleles were analyzed using polymerase chain reaction. We found significant increases in HLA-A2, -B17, -B37 and -B13 antigens and highly significant increases in HLA-Cw*0602 and DR7 antigens in psoriatic patients compared with controls. Patients with type I psoriasis (early onset, positive family history) showed highly significant associations with Cw*0602 [p < 0.00001 ; relative risk (RR) = 14.45] and DR7 (p < 0.00001 ; RR = 15.09) antigens. Patients with type II psoriasis (late onset, no family history) had a significant association with Cw*03 antigen (p = 0.008 ; RR = 0.17). In conclusion, HLA-B13, -B17, Cw*0602 and -DR7 antigens are associated with a significant risk of psoriasis in the Croatian population and the Cw*0602 allele has the strongest association, especially for type I psoriasis.

analysis; HLA antigens; Croatian patients; psoriasis

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Podaci o izdanju

211 (Suppl. 211)

2000.

12-13

objavljeno

0001-5555

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost