Type I psoriasis is associated with CW*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 extended haplotype in the Croatian population (CROSBI ID 546394)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kaštelan, Marija ; Čečuk, Esma ; Grubić, Zorana ; Gruber, Franjo ; Brajac, Ines ; Prpić-Massari, Larisa ; Kaštelan, Andrija
engleski
Type I psoriasis is associated with CW*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 extended haplotype in the Croatian population
The inheritance of psoriasis is polygenic. One locus is with certainity located within the 6p chromosome MHC region. Due to linkage disequilibrium in MHC region, Cw6 allele is associated with B57, DRB1*0701, DQA1*0201 and DQB1*0201 or DQB1*0303 alleles, forming the Caucasian extended haplotype EH-57.1 named according to the B allele. We therefore analyzed the distribution of Caucasian extended haplotype in Croatian patients with psoriasis by hibridization with specific oligonucleotides. Type I psoriasis (early onset, positive family history) showed significant association with DRB1*0701 (p 0.00001), DQA1*0201 (p 0.00001), DQB1*0201 (p=0.0006) and DQB1*0303 alleles (p=0.0008). Patients with type II psoriasis (late onset, no family history) did not show association with any class II alleles. The Caucasian extended haplotype Cw*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 was with significantly higher frequency present in type I patients (p 0.00001 ; RR=7.72). This haplotype did not appear at all in type II psoriatics. Our results show that type I but not type II psoriasis is associated with Cw*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 extended haplotype in Croatian population.
type I psoriasis; CW*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 haplotype; Croatian population
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Podaci o prilogu
2002.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
JEADV
Podaci o skupu
10th Congress of European Academy of Dermatology and Venereology
poster
02.10.2002-06.10.2002
Prag, Češka Republika