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Epilepsy and clinical syndromes of malformations of cortical development in a paediatric population. (CROSBI ID 546465)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Cvitanović-Šojat, Ljerka ; Šepić Grahovac, Dubravka ; Hanzić, Tomislav-Franjo ; Mataija, Marina, Sojat, Tina Epilepsy and clinical syndromes of malformations of cortical development in a paediatric population. // Abstracts. Epilepsia Volume 43 – Supplement 8 / Serratosa, Jose M (ur.). Madrid: International League Against Epilepsy, Blackwell Publishing, 2002. str. 194-x

Podaci o odgovornosti

Cvitanović-Šojat, Ljerka ; Šepić Grahovac, Dubravka ; Hanzić, Tomislav-Franjo ; Mataija, Marina, Sojat, Tina

engleski

Epilepsy and clinical syndromes of malformations of cortical development in a paediatric population.

Advances in modern imaging have allowed recognition during life of several malformations of cortical development (MCD) associated with/manifested by epilepsy. Our purpose was to review all the cases with MCD and to attempt to correlate them with the type and severity of epilepsy. We made a retrospective analysis of clinical reports and cerebral CT/MRI of patients with MCD referred to our Neuropaediatric Unit between 1991 and 2001. Imagines were analysed by the neuroradiologists and classified according to Barkovich’ s classification (Barkovich AJ et al. Neurology 2001 ; 57:2168). There were 5 girls and 5 boys, aged 1 to 9 years at an initial imaging. Seizures were the first manifestation of MCD in 6/10 patients ; abnormal neurological findings/developmental delay in 4/10.The different types of main malformations identified were focal subcortical heterotopia in 3/10, subependimal heterotopia and schizencephaly in 4/10, bilateral perisylvian syndrome in 1/10 and lissencephaly in 2/10. Epilepsy occurred between 1.5 and 8 years of age in 8/10 ; 4 had good control of epilepsy, 3 had refractory epilepsy, and 1 had been in remission for 7 years. Normal neurological status was found in 6/10 ; hemiplegia with atrophy of the same side of the body in 4/10, normal intellectual level in 3/10 ; borderline intellectual functioning in 4/10 ; severe psychomotor retardation in 3/10. Identification of MCD and their associated epileptic syndromes represent a major advance in the understanding of intractable epilepsy. Very little distinction exists in respect to clinical, electrographic, therapeutic and prognostic aspects, which may be characteristic of specific types of MCD.

Epilepsy; Brain malformations; Childhood

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Podaci o prilogu

194-x.

2002.

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objavljeno

Podaci o matičnoj publikaciji

Abstracts. Epilepsia Volume 43 – Supplement 8

Serratosa, Jose M

Madrid: International League Against Epilepsy, Blackwell Publishing

Podaci o skupu

5th European Congress on Epileptology 6-10.10.2002

poster

06.10.2002-10.10.2002

Madrid, Španjolska

Povezanost rada

Kliničke medicinske znanosti