Epilepsy and Cerebellar Atrophy (CROSBI ID 546473)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Šepić Grahovac, Dubravka ; Cvitanović-Šojat, Ljerka ; Willheim, Ksenija ; Jurjević, Ante ; Papa, Jurica
engleski
Epilepsy and Cerebellar Atrophy
Adverse neurological effects of antiepileptic drugs to control seizures in epilepsy are well documented. Published literature on MRI of the brain has shown an association between cerebellar atrophy and the long-term antiepileptic drugs therapy in patients with epilepsy. We report a 20-year old patient with cerebellar ataxia, dysarthria and severe epilepsy. He had had normal development until age 7, when partial motor (right) and generalized tonic-clonic seizures had onset. EEG shoved diffuse paroxysmal changes, with multiple spike wave and spike discharges. Results of CT of the brain were normal, and results of tests for possible neurometabolic diseases showed average values. The past 13 years he has been treated with high doses of phenytoin, phenobarbital and valproate, with only partial success. He now has psychological and memory disturbances. Epileptic seizures have become rare this year, but cerebellar ataxia and dysarthria are present. MRI of the brain shows enormous cerebellar atrophy. Cerebellar atrophy is now considered a possible consequence of long-term treatment with antiepileptic drugs, especially phenytoin. In our patient, MR neuroimaging contributed to detection of etiological factors of neurological deficits.
Epilepsy; Phenytoin; cerebellar atrophy
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Podaci o prilogu
73-x.
1998.
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objavljeno
Podaci o matičnoj publikaciji
Abstracts. Epilepsia Volumne 39 - Suppl.2
New York (NY): Raven Press
Podaci o skupu
Third European Congress of Epileptology
poster
24.05.1998-28.05.1998
Varšava, Poljska