engleski

Continuous glucose monitoring system based on microdialysis in assessment of glycaemia in type 2 diabetic microalbuminuric patients – a pilot study

Background and Aims:The progression of diabetic nephropathy is related to the degree of glycemic control. We used the continuous glucose monitoring system based on microdialysis (GlucoDay, A.Menarini) to evaluate blood glucose excursions in microalbuminuric type 2 diabetic patients. Patients and methods: Fifty type 2 diabetic and microalbuminuric ( rate of albumin excretion 20-199 ug/min) patients on two times/day NPH insulin and before meals three times/day lispro insulin were enrolled in our pilot study. Their characteristics were as follows: 24 male, 26 female, mean age 65 years, diabetes duration 9, 8 +3, 2 years, mean HbA1c was 8, 33 % + 1, 08 %. A 48 hours monitoring was obtained to all patients on the beginning and after 3 months observation period. The information was downloaded and analysed retrospectively by a diabetologist. Results: At baseline, time spent in the euglycemic range (glucose between 3.9 and 8.0 mmol/l) was 46, 87 &plusmn ; 10, 22 %. At end point, time in the euglycemic range increased on 62, 37 &plusmn ; 12, 20 %. Time spent in the hypoglycemic range (glucose below 3.9 mmol/l) was 9.23 &plusmn ; 2.83 % at baseline. At end point, time in the hypoglycemic range decreased 6.6 &plusmn ; 1.68 %. HbA1c was significantly improved from the value 8.33 &plusmn ; 1.08 % observed at the beginning to 7.64 &plusmn ; 0, 92 % after 3 months. Conclusions: This pilot study suggested that continuous glucose monitoring offers to diabetics and diabetologists more informations about glucose excursions and influences on achieving better metabolic control.

continuous glucose monitoring; diabetic nephropathy

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