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izvor podataka: crosbi

Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems (CROSBI ID 86251)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ramljak, Sanja ; Hackenberger, Branimir ; Smital, Tvrtko ; Britvić, Smiljana Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems // Journal of environmental science and health. Part B, 35 (2000), 6; 751-770

Podaci o odgovornosti

Ramljak, Sanja ; Hackenberger, Branimir ; Smital, Tvrtko ; Britvić, Smiljana

engleski

Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems

The effect of the herbicide Dicuran 500 FL (formulated product) on the phenotypical and genotypical changes in procaryotic and eucaryotic organisms was investigated using short-term tests for detecting genotoxins. Since pesticides discharged in the water environment can modulate the mixed-function monooxygenases (MFO) detoxification system of water organisms, the in vivo and in vitro effects of Dicuran on hepatic cytochrome P450 (cyt P450) monooxygenase activities were also examined in juvenile carp (Cyprinus carpio L.). By measuring the activities of MFO in experimental carp exposed to Dicuran an attempt was made to establish whether Dicuran could be bioactivated by MFO into ultimate mutagens. Our results on the bacterial strains Salmonella typhimurium TA100 and TA98 show that Dicuran does not possess either mutagenic or premutagenic characteristics. The micronucleus test on the erythrocytes of experimental carp did not establish any clastogenic effect either. However, Dicuran significantly inhibited the MFO activity of 7-ethoxyresorufin-O-deethylase (EROD) and benzo[a]pyrene monooxygenase (BaPMO) in the liver of experimental carp in vitro, as well as in in vivo conditions. These findings demonstrate the potentially damaging effect of Dicuran on the xenobiotic metabolizing enzyme systems of fish, and suggest the applicability of described methods for the prediction of the ecotoxicological significance of the presence of pesticides in the water environment.

Dicuran 500 FL; chlortoluron; genotoxicity; Ames test; micronucleus test; MFO; EROD; BaPMO; inhibition; fish

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Podaci o izdanju

35 (6)

2000.

751-770

objavljeno

0360-1234

Povezanost rada

Kemija

Indeksiranost