engleski

The basis of topical superoxide dismutase antipruritic activity

In humans, as in all mammals and most chordates, three forms of superoxide dismutase (SOD) are present: SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. SOD is used in cosmetic products to reduce free radical damage to the skin, for example, to reduce fibrosis following radiation for brease cancer. Pruritus is one of the most common symptoms of skin diseases, but can also be a major symptom of systemic diseases (e.g. malignancy, infection or metabolic disorders). There are various antihistaminics used as antipruritogenic substances. In the genesis of the pruritus there are many pruritogens involved. On many ocassions we observed that topical SOD seemed to possess strong antipruritic activity. We analyzed literature data on the effect of SOD as an antipuritogen on NK-1 receptors and proinflammatory cytokines, its regulatory role in calcitonin gene-related peptide production and expression, dow-regulation of TNF-alfa and numerous cytokines, and suppression of nitric oxide production.

pruritus; itch; topical superoxide dismutase; opioids

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