Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation (CROSBI ID 149285)
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Podaci o odgovornosti
Rajić, Zrinka ; Kos, Gabrijela ; Zorc, Branka ; Singh, Prati Pal ; Singh, Savita
engleski
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation
New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type poly  ,  -(N-2-hydroxyethyl-DL-aspartamide) (PHEA) and poly  ,  -(N-3-hydroxypropyl-DL-aspartamide) (PHPA) were synthesized, characterized and screened for their antimalarial activity. The conjugates differed in type of covalent bounding, length of spacer between the polymeric carrier and drug, molecular masses and drug-loading. Blood-schizontocidal activity of the prepared conjugates was tested against Plasmodium berghei infection in Swiss mice. Polymeric conjugates showed better antimalarial activity than the glucosamine conjugate.
primaquine; polymer-drug conjugate; polyaspartamide; glucosamine; antimalarial activity
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Podaci o izdanju
Povezanost rada
Kemija, Farmacija