Evaluation of the Reliability of DNA Typing in the Process of Identification of War Victims in Croatia (CROSBI ID 149286)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Džijan, Snježana ; Ćurić, Goran ; Pavlinić, Dinko ; Marcikić, Mladen ; Primorac, Dragan ; Lauc, Gordan
engleski
Evaluation of the Reliability of DNA Typing in the Process of Identification of War Victims in Croatia
Aiming to estimate frequency of various types of errors that can occur in large scale process of identification, we identified and compared genotypes of 911 parent– child pairs in the database of 3498 relatives of people that disappeared during 1991/1992 war in Croatia. Genotypes of 891 pairs (97.8%) were matching, while 20 pairs did not match in one or more loci. Reanalysis of these samples revealed that out of 1822 analyzed genotypes, one genotype was completely wrong, and two genotypes had one wrong allele because of human errors. Five genotypes had a single wrong allele due to either PCR or electrophoresis errors. In five genotypes mutations were the cause of mismatch. Genetic inconsistencies with parentage were found in four “ fathers” (4.2%) and three “ mothers” (0.36%). Since the majority of observed single-locus errors were caused by non-human errors all databases produced with similar technology would probably have comparable level of errors.
forensic science; DNA typing; human identification; quality control; databasing; paternity
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Podaci o izdanju
54 (3)
2009.
608-609
objavljeno
0022-1198
10.1111/j.1556-4029.2009.01015.x
Povezanost rada
Temeljne medicinske znanosti, Biologija