engleski

Translocation (1 ; 3)(p36 ; q21) at relapse in a child with acute myeloid leukemia and normal karyotype at diagnosis

We present a 6-year-old girl with acute myeloid leukemia (AML)-M5, normal karyotype at the time of diagnosis, and t(1 ; 3)(p36 ; q21) at relapse. The t(1 ; 3)(p36 ; q21) is a rare but recurrent chromosomal aberration in human malignancies that it is primary observed in adults but is extremely rare in children. To the best of our knowledge, only one child with MDS and t(1 ; 3)(p36 ; q21) has been reported in the literature so far. Our case is the second report of this translocation in a child. According to the first report, the t(1 ; 3) was not observed at diagnosis, but was found after chemotherapy and adds new evidence of an association between t(1 ; 3) and previous exposure to cytotoxic agents.

translocation (1; 3); AML; relaps

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