engleski

The phytohormone auxin induces G1 cell cycle arrest of human tumor cells

The plant hormone auxin is the key regulator of plant growth and development. Auxin regulates transcription of plant genes by targeting transcriptional repressor Aux/IAA to degradation. While there are many reports describing its potential to modulate human cell functions, the majority is based on auxin action following enzymatic activation. A study focused on auxin alone and its antiproliferative potential, with the emphasis on the modulation of the cell cycle, has not been performed. Therefore, we analyzed tumor growth inhibitory effect and the cell cycle perturbations of natural (IAA, IBA) and synthetic (NAA, 2, 4-D) auxins. All derivatives showed cytostatic effect on selected human tumor cell lines. The cell cycle analysis revealed that IAA and 2, 4-D induce strong G1 arrest, along with drastic decrease of S phase-cells percentage in MCF-7 cell line. This phenomenon points that auxins may have a novel unexploited antitumor potential and should be further investigated.

IAA ; IBA ; NAA ; 2 ; 4-D ; human tumor cells ; G1 arrest

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