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Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats (CROSBI ID 149880)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ilić, Spomenko ; Drmić, Domagoj ; Žarković, Kamelija ; Kolenc, Danijela ; Ćorić, Marijana ; Brčić, Luka ; Kliček, Robert ; Radić, Božo ; Sever, Marko ; Djuzel, Viktor et al. Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats // European journal of pharmacology, 667 (2011), 1-3; 322-329. doi: 10.1016/j.ejphar.2011.05.038

Podaci o odgovornosti

Ilić, Spomenko ; Drmić, Domagoj ; Žarković, Kamelija ; Kolenc, Danijela ; Ćorić, Marijana ; Brčić, Luka ; Kliček, Robert ; Radić, Božo ; Sever, Marko ; Djuzel, Viktor ; Ivica, Mihovil ; Boban Blagaić, Alenka ; Zoričić, Zoran ; Anić, Tomislav ; Zoričić, Ivan ; Džidić, Senka ; Seiwerth, Sven ; Sikirić, Predrag

engleski

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

We challenged rats with chronic ibuprofen application (0.4g/kg intraperitoneally once daily for 4 weeks) and the stable gastric pentadecapeptide BPC 157 therapy. We evidenced a deleterious circuit not reported in ibuprofen-rats as yet: hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values, with prolonged sedation/unconsciousness and weight loss. In particular, ibuprofen toxicity exhibited itself as brain edema and cyanosis, particularly in the cerebellum, more so in white than in gray mater, damaged (balonized) red neurons, without any inflammatory reaction, particularly in the cerebral cortex and cerebellar nuclei, less in the hippocampus, dentate nucleus and Purkinje cells. BPC 157 (GEPPPGKPADDAGLV, MW 1419, 10µ ; g, 10ng/kg) was fully effective given as an antidote after ibuprofen: (i) intraperitoneally, immediately after ibuprofen or (ii) in drinking water (0.16 µ ; g, 0.16 ng/ml) until the end of the 4 week-experiment. Thus, apart from its role as an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL14736) and various wound treatment, with no toxicity reported and which already showed various hepatoprotective effects, either BPC 157 regimen counteracted

paracetamol ; hepatic encephalopathy ; convulsions ; pentadecapeptide BPC 157 ; rats

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Podaci o izdanju

667 (1-3)

2011.

322-329

objavljeno

0014-2999

1879-0712

10.1016/j.ejphar.2011.05.038

Povezanost rada

Temeljne medicinske znanosti

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