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Tumor-Associated Tissue Eosinophilia and Inflammation in pTa and pT1 Papillary Urothelial Carcinoma of Urinary Bladder (CROSBI ID 149969)

Prilog u časopisu | Pismo (znanstveno) | međunarodna recenzija

Marušić, Zlatko ; Čupić, Hrvoje ; Krušlin, Božo ; Tomas, Davor ; Milošević, Milan ; Mikuz, Gregor Tumor-Associated Tissue Eosinophilia and Inflammation in pTa and pT1 Papillary Urothelial Carcinoma of Urinary Bladder // Analytical and quantitative cytology and histology, 31 (2009), 4; 239-241. doi: 2009-482FT-0006

Podaci o odgovornosti

Marušić, Zlatko ; Čupić, Hrvoje ; Krušlin, Božo ; Tomas, Davor ; Milošević, Milan ; Mikuz, Gregor

engleski

Tumor-Associated Tissue Eosinophilia and Inflammation in pTa and pT1 Papillary Urothelial Carcinoma of Urinary Bladder

The presence of lamina propria invasion is a prominent prognostic factor in papillary urothelial carcinoma of the bladder. Pathologic assessment of lamina propria invasion is frequently difficult due to the inevitable tangential sectioning and other factors, such as thermal and/or mechanical artifacts or pronounced stromal inflammation that may obscure invasion.1 Recent studies performed on cervical, vulvar and laryngeal carcinoma2-4 suggest that an elevated stromal eosinophil count may serve as a morphologic feature associated with tumor invasion. We performed a study to test the hypothesis that a high stromal eosinophil count and intense stromal inflammation are indicative of lamina propria invasion in papillary urothelial carcinoma of the bladder. Our aim was also to estimate the number of eosinophils per 1 high power field (HPF) and per 10 HPFs that could serve as thresholds in the diagnosis of invasion. The computer database at the Ljudevit Jurak Department of Pathology was used to generate a list of 50 consecutive patients with pTa and pT1 papillary urothelial carcinoma of the bladder each treated with transurethral resection, starting on January 1, 2005. The age of patients ranged from 35 to 87 years (median, 67.4), and the male:female ratio was 4.5:1. There was no statistically significant difference in the age (Mann-Whitney U-test, p> 0.05) or sex distribution (c2 test, p>0.05) between the pTa and pT1 groups. Thirty-one (62%) pT1 and 4 (8%) pTa tumors were high grade. Eosinophils were counted in lamina propria in an HPF (400•) with the maximal number of eosinophils and in 9 adjacent HPFs (Table I). The average number of inflammatory cells in 1 HPF was calculated from 10 randomly selected HPFs in lamina propria and graded as 0: <50 inflammatory cells/HPF, 1: 50-100 inflammatory cells/HPF, 2: 101-200 inflammatory cells/HPF and 3: >200 inflammatory cells/HPF.

eosinophilia; inflammation; pTa; pT1; papillary urothelial carcinoma; urinary bladder

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Podaci o izdanju

31 (4)

2009.

239-241

objavljeno

0884-6812

2009-482FT-0006

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost