engleski

Placental Angiogenesis in Diabetic Pregnancy

Vascular endothelial growth (VEGF) factor and placental growth factor (PlGF) are key factors in physiological and pathological conditions of pregnancy. The aim of the study was to analyze whether serum levels of PlGF in mother’ s and umbilical blood are differentiated between healthy pregnant women and pregnant women suffering from type-1 diabetes mellitus. We performed a prospective study of 44 pregnant women with type 1 diabetes mellitus who did not have diabetes complications and of 34 healthy pregnant women of the adequate age and parity and the normal pregnancy course. Statistical analysis was performed using ANOVA, Student t-test, linear regression, and non-parametrical Man-Whitney U test. PlGF level in diabetic and healthy pregnant women from the 8th till the 15th week of pregnancy is comparatively low, and after the 15th week of pregnancy it increases fast till the 31st week of pregnancy when the value is the highest. After the 31st week of pregnancy there is a decrease of PlGF level. Comparing PlGF values between the research groups in certain weeks of pregnancy no statistically significant difference was found. PlGF values in serum of pregnant healthy women and pregnant women with type 1 diabetes mellitus do not differ in certain weeks of pregnancy.

placental angiogeneses; placental growth factor; vascular endothelial growth factor

Rad je prezentiran na skupu XXI. European Congress of Perinatal Medicine ((ECPM)), održanom od 10.-13.09.2008., Istanbul, Turska.