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H-ras gene polymorphisms and sporadic colon cancer in Croatian population (CROSBI ID 548575)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Catela Ivković, Tina ; Kapitanović, Sanja H-ras gene polymorphisms and sporadic colon cancer in Croatian population // European journal of human genetics / ESHG (ur.). 2009. str. 174-174

Podaci o odgovornosti

Catela Ivković, Tina ; Kapitanović, Sanja

engleski

H-ras gene polymorphisms and sporadic colon cancer in Croatian population

High incidence of colon cancer worldwide indicates the importance of exploring genetic alterations that lead to its carcinogenesis. Two polymorphisms in H-ras gene, hexanucleotide tandem repeats in the first intron and SNP T81C in the first exon, that might be connected with susceptibility to cancer have been described. The aim of our study was to investigate these loci in Croatian population and to determine if any of them is connected with susceptibility to colon cancer. Two hundred healthy volunteers and 200 colon cancer patients were genotyped using PCR and RFLP methods. Frequencies at hexanucleotide locus were 44, 5%, 22, 5%, 5, 5%, 7%, 1% and 19, 5% in healthy population, and 49%, 26%, 3, 5%, 2, 5%, 5, 5% and 13, 5% in colon cancer for P1/P1, P1/P2, P2/P2, P2/P3, P3/P3 and P1/P3 genotype respectively. Allele frequencies were 65, 5%, 20, 3% and 14, 2% in healthy population and 68, 8%, 17, 8% and 13, 5% in colon cancer for P1, P2 and P3 respectively. For SNP T81C locus frequencies were 42, 5%, 42, 5% and 15% in healthy population and 62, 5%, 35% and 2, 5% in colon cancer for TT, TC and CC respectively. Allele frequencies were 63, 8 % and 36, 2% in healthy population and 80% and 20% in colon cancer for T and C alleles respectively. Genotype P3/P3 was more common in colon cancer patients and P2/P2 and P2/P3 genotypes in healthy population. Allele -81C was more common in healthy volunteers in comparison to colon cancer patients.

H-ras; polymorphisms; sporadic colon cancer

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Podaci o prilogu

174-174.

2009.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

European journal of human genetics

ESHG

Beč: Nature publishing group

1018-4813

Podaci o skupu

European Human Genetics Conference 2009

poster

23.05.2009-26.05.2009

Beč, Austrija

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost