engleski

Neuromagnetic auditory activity reflects differences between normal aging, MCI and AD subjects: An oddball study

Neuromagnetic source localization was conducted on data obtained from an auditory oddball task to examine alterations in cortical neurodynamics, particularly in medial temporal lobes (MTL), of patients diagnosed as MCI and AD relative to age-matched healthy elderly. MEG data were recorded with a CTF 275-channel whole-head system in a magnetically shielded room at the MIND Institute. The auditory oddball task consisted of 400 frequent (1.000 Hz, p=0.8) and 100 rare (1.200 Hz, p=0.2) binaurally presented tones. Calibrated Start Spatio-Temporal (CSST) modeling, launched from within MRVIEW, was used for source localization and cortical temporal dynamics estimation. Differences noted in the cortical activation patterns were: 1) early unilateral MTL activation to rare stimuli in AD compared to bilateral activation in healthy elderly and MCI and 2) reduced and/or altered late MTL activity for both rare and frequent stimuli in MCI and AD patients relative to healthy elderly. Both findings suggest that MTL activity patterns may provide important information for discriminating between participant diagnostic categories.

MEG; auditory add ball paradigm; cortical neurodynamics; aging; MCI; AD

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