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New insights into maternal-fetal interactions at implantation (CROSBI ID 150935)

Prilog u časopisu | izvorni znanstveni rad

Chaouat, Gerard ; Zourbas, Sandrine ; Ostojić, Saša ; Lapprée Delage, Genevieve ; Dubanchet, Sylvie ; Ledee-bataille, Natalie ; Martal, Jacques New insights into maternal-fetal interactions at implantation // Reproductive biomedicine online, 2 (2001), 3; 198-203

Podaci o odgovornosti

Chaouat, Gerard ; Zourbas, Sandrine ; Ostojić, Saša ; Lapprée Delage, Genevieve ; Dubanchet, Sylvie ; Ledee-bataille, Natalie ; Martal, Jacques

engleski

New insights into maternal-fetal interactions at implantation

The immunotrophic theory was enunciated by Tom Wegmann. Since then, the involvement of cytokines in implantation and materno-fetal tolerance has emerged as a central topic in reproductive immunology. This brief survey covers the historical background leading to the specification of the crucial role of cytokines at the feto-maternal interface, and the present known patterns of their function. Focus is addressed to the most recent concept, e.g. pregnancy as a Th2 phenomenon (the immune response of the mother is biased towards the production of anti inflammatory cytokines, amongst them IL-10 which suppress inflammatory responses). A brief description of the role of inflammatory cytokines in implantation is presented to explain why it does not fit into such a scheme, and other recent data, for example on gamma interferon, also fails to accord with the Th2 phenomenon.

cytokines; immunology; implantation; materno– fetal interactions; pregnancy

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Podaci o izdanju

2 (3)

2001.

198-203

objavljeno

1472-6491

1472-6491

Povezanost rada

Temeljne medicinske znanosti

Poveznice