New insights into maternal-fetal interactions at implantation (CROSBI ID 150935)
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Podaci o odgovornosti
Chaouat, Gerard ; Zourbas, Sandrine ; Ostojić, Saša ; Lapprée Delage, Genevieve ; Dubanchet, Sylvie ; Ledee-bataille, Natalie ; Martal, Jacques
engleski
New insights into maternal-fetal interactions at implantation
The immunotrophic theory was enunciated by Tom Wegmann. Since then, the involvement of cytokines in implantation and materno-fetal tolerance has emerged as a central topic in reproductive immunology. This brief survey covers the historical background leading to the specification of the crucial role of cytokines at the feto-maternal interface, and the present known patterns of their function. Focus is addressed to the most recent concept, e.g. pregnancy as a Th2 phenomenon (the immune response of the mother is biased towards the production of anti inflammatory cytokines, amongst them IL-10 which suppress inflammatory responses). A brief description of the role of inflammatory cytokines in implantation is presented to explain why it does not fit into such a scheme, and other recent data, for example on gamma interferon, also fails to accord with the Th2 phenomenon.
cytokines; immunology; implantation; materno– fetal interactions; pregnancy
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