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Propolis and plant flavonoids in human allergies and inflammations

There is growing recognition that many polyphenolic compounds presents in most plants and bee products such as propolis may have beneficial effect on human health. Epidemiological studies have revealed the important role that foodstuffs of vegetable origin have to play an important role in the prevention of numerous illnesses including allergic inflammatory diseases such as allergic rhinitis, asthma, rheumatoid atritis, skin inflammation and bowel diseases.The natural antioxidants present in such foodstuffs, among which the flavonoids are widely present, may be responsible for such an activity. They may be of great utility in states of allergic rinitis, asthma, accute or chronic diarrhoea through the inhibition of intestinal secretion and motility may also be beneficial in the reduction of chronic inflammatory damage in the intestine, by affording protection against oxidative stress and by preserving mucosal function. This article reviews in short molecular mechanism involved in development of respected disorders, the relationship between flavonoids present in bee products and plants and allergy and inflammation, respectively based on various in vivo and in vitro studies. It also describes current understandings of the possible mechanisms of influence of flavonoids and multiple beneficial effects in combating allergy and allergy-related complications. Taken together, this information provides a basis for multimodal therapeutic effects of propolis, plants and related flavonoids on allergy. Finally, this article presents an overview of various aspect of the pathobiology of allergy and allergy related complication and an ability of molecular approaches in their treatments.

Propolis, Flavonoids, Human allergies, Inflamatory bowel diseases

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