engleski

Alterations in some blood coagulation parameters in naturally occurring cases of canine babesiosis

We examined changes in coagulation parameters in dogs naturally infected (n=30) with Babesia canis canis and hemostasis was evaluated and compared to values obtained from healthy dogs (n=29). To date, there have not been any studies examining the dynamics of thrombin-antithrombin complex formation in cases of canine babesiosis. Coagulation parameters evaluated before (day 0) and on days 1, 2, and 3 after treatment with imidocarb (6 mg/kg inj. s/c) included determining platelet counts, the formation of thrombin-antithrombin complexes (TAT), prothrombin time (PT), activated partial thromboplastin time (APTT) and antithrombin III (AT III) activity. TAT complexes were significantly elevated in animals with babesiosis on days 0 and 2 (mean 49.7 and 87.7 µ ; g/L vs. control, 7.2 µ ; g/L). AT III activity was significantly decreased at all time points examined. There were no differences in PT. On days 2 and 3 the APTT was significantly shortened in the infected dogs when compared to control animals (means of 21.3 and 19.2 s compared to control, 30.0 s). Our analysis demonstrated that infected dogs had significant thrombocytopenia during the course of the study (mean day 0 - 29x109/L, day 1 - 48x109/L, day 2 - 47x109/L and day 3 - 87 x109/L, vs. control - 259 x109/L). These data suggested that babesiosis in dogs compromises primary and secondary hemostasis and that induction of disseminated intravascular coagulation (DIC) occurs in canine babesiosis.

dog; Babesia canis; hemostasis; coagulation

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