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Impaired lung function in children with allergic rhinitis without asthma (CROSBI ID 549481)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Mrkić Iva ; Plavec Davor ; Nogalo Boro ; Turkalj Mirjana. Impaired lung function in children with allergic rhinitis without asthma. 2008

Podaci o odgovornosti

Mrkić Iva ; Plavec Davor ; Nogalo Boro ; Turkalj Mirjana.

engleski

Impaired lung function in children with allergic rhinitis without asthma

Inflammatory markers present in asthma can be elevated in patients with allergic rhinitis. Aim of our study was to evaluate lung function together with level of exhaled NO(eNO) in patients with allergic rhinitis without asthma.Subjects and methods:In a group of 51 children(31 male, 4-19 yrs) with diagnosed allergic rhinitis without asthma, we measured lung fuction, eNO, evaluated allergen sensitivity (skin prick tests, specific IgE) and therapy. Results: Twenty-two patients were allergic to pollen, 3 to mites, 10 to other perennial allergens, 12 to pollen and mites, and 3 were multisensitized. Spirometry showed restriction in 4% patients (FVC<80%predicted), while up to 13% had at least a distinct obstruction in the area of small airways (MEF25 or MEF50<80%), and up to 27% in the area of large airways (MEF75ofPEF<80%).Patients receiving intranasal corticosteroid (INCS)therapy plus antihistamines had the best PEF. In 25 patients we found elevated eNO. The lowest eNO values were found in patients receiving only INCS, and the highest in patients receiving triple rhinitis therapy(INCS+antihistamines+leukotriene antagonist).Significant correlation between eNO and lung function (FVC, P=0.004 ; FEV1, P=0.006) was found. Better lung function was found in patients with higher level of eNO.Conclusion: It seems that allergic rhinitis in children can be related to impaired lung function without clinical symptoms of lower airways.As these children may have increased risk for asthma they deserve further monitoring.

Rhinitis; lung function; eNO

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Podaci o prilogu

2008.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

7th Symposium on Expermental Rhinology and Immunology of the Nose

predavanje

13.11.2008-15.11.2008

Dubrovnik, Hrvatska

Povezanost rada

Kliničke medicinske znanosti