engleski

PLASMA CYTOKINES AS EARLY MARKERS OF ASEPTIC PROSTHESIS LOOSENING – PRELIMINARY RESULT

BACKGROUND: The proinflammatory cytokines IL-1 ß, IL-8, and TNF-α play a major role in the process of bone resorption during aseptic loosening of large joint prostheses. Our reported data suggest elevated plasma levels of proinflammatory cytokines may be useful as markers of bone resorption in the laboratory diagnosis of prosthesis loosening. AIM: The objective was to evaluate if elevated plasma levels of proinflammatory cytokines may be usefull as early markersof bone resorption in patients with arthroplasties free from clinical, radiological signs of lossening. SUBJECTS AND METHODS: We followed-up 50 patients with stable prostheses without clinical and radiological signs of prosthesis loosening. In order to achive proof that elevated plasma levels of proinflammatory cytokines of IL-1 ß, IL-8, and TNF-α ; may be usefull as markers of bones resorption we made preliminary clinical and radiological examination of those patients from 2003 to 2006. RESULTS Among 50 patients with stable prostheses five of them had elevated levels of IL-1 ß, IL-8, and TNF-α in 2003. During examination in 2006 only one of those patients with stable prostheses had clinical and radiological signs of loosening. We must point out that he had elevated plasma levels of proinflammatory cytokines in 2003. CONCLUSION: This preliminary resultr encourages us to futher follow up that group of patients in order to achieve proof that elevated plasma level of proinflammatory cytokines in patients with stable prostheses may be usefull as early markers of bone resorption in the laboratory diagnosis of prosthesis loosening.

Plasma cytokines; Markers; Prothesis loosening

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