engleski

Protective effects of met-enkephalin on alcohol induced gastric lesions

The model of ethanol induced gastric lesions is useful in the evaluation of gastric cytoprotection. We used it to measure cytoprotective effects of two neuropeptides, Met-enkephalin (Peptid-M, LUPEXŇ) and a-melanocyte stimulating hormone (a-MSH). Both peptides exhibited significant and synergistic cytoprotective effects. The bect therapeutic efficacy was obtained with Met-enkephalin and a-MSH mixture 3-5 : 1. Significant cytoprotective action on ethanol induced lesions was also observed by means of two thymus peptide fractions, Thymus Peptide Câ and JAN 50â. Thymus Peptide Câ exhibited significant synergistic effect with Met-enkephalin while JAN 50â did not. In addition to the cytoprotection of rat gastric mucosa Met-enkephalin also induced statistically significant and dose dependent Straub tail response versus control (in mice). Haloperidol, naloxone and Peptide-D antagonised its effects. NMR spectrospic findings of Met-enkephalin and haloperidol confirmed molecular interactions of both substances.

met-enkephalin; alpha-MSH; ethanol; gastric lesions; cytoprotection; haloperidol; NMR

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