engleski

Peroxidation and Age-Associated Diseases-Cause or Consequence?

Aging is progressive and deleterious process in many aspects common to all living organisms. In humans, development of various diseases, such as neurodegenerative diseases, cardiovascular diseases, some forms of cancer, metabolic disorders, diabetes, certain autoimmune and bone diseases, is proportional to aging. Therefore, it seems that excess in production of reactive oxygen species causing oxidative stress and lipid peroxidation plays important role in aging, homeostasis and initiation of age-associated diseases. Hence, oxidative stress and lipid peroxidation could be considered both as causative for particular age-associated diseases as well as cofactors of aging. However, constant but moderate oxidative stress might have beneficial impact upon increment of antioxidative capacities thus preventing initiation of age-associated diseases and extending aging.

aging ; oxidative stress ; lipid peroxidation ; 4-hydroxynonenal

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