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Reg IV protein and mRNA expression in different rat organs (CROSBI ID 151768)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ažman, Josip ; Starčević–Klasan, Gordana ; Ivanac, Danijel ; Picard, Anne ; Jurišić–Eržen, Dubravka ; Nikolić, Marina ; Malnar, Daniela ; Arbanas, Juraj ; Jerković, Romana Reg IV protein and mRNA expression in different rat organs // Acta histochemica, 113 (2011), 8; 793-797. doi: 10.1016/j.acthis.2010.11.008

Podaci o odgovornosti

Ažman, Josip ; Starčević–Klasan, Gordana ; Ivanac, Danijel ; Picard, Anne ; Jurišić–Eržen, Dubravka ; Nikolić, Marina ; Malnar, Daniela ; Arbanas, Juraj ; Jerković, Romana

engleski

Reg IV protein and mRNA expression in different rat organs

The Reg IV gene has been documented in the human colon, small intestine, stomach and pancreas. Expression of the Reg IV in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. Since the distribution of the Reg IV protein in normal rat tissue is unknown, the aim of this study was to reveal the expression of the Reg IV protein in structurally and functionally different rat organs. The expression of Reg IV gene was analyzed by Western blot and reverse transcription-polymerase chain reaction. Immunohistochemistry was used to localize Reg IV protein. Reg IV protein was expressed in pancreas, stomach, small intestine, colon, brain, spleen, kidney and urinary bladder in two-month-old rats. In addition, the expression of Reg IV mRNA by reverse transcription-polymerase chain reaction was confirmed. Our study provides detailed information about the expression and localization of Reg IV protein in different rat organs. These findings provide an evidence of Reg IV expression in different rat organs, which may help elucidate a potential role in growth and proliferation of different cells like other members of the Reg family genes which act as growth factors in the different organs.

reg IV; immunohistochemistry; western blot; rat; gene expression; rat

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Podaci o izdanju

113 (8)

2011.

793-797

objavljeno

0065-1281

10.1016/j.acthis.2010.11.008

Povezanost rada

Temeljne medicinske znanosti

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