engleski

A critical size for palindrome induced intrachromosomal recombination in yeast

While short palindromes are important DNA motifs frequently found in different cis-acting genetic elements longer palindromic sequences are highly unstable in various organisms. SInce recombinogenicity of a palindrome is clearly size-related we decided to investigate how thw step-by-step increase in the size of a palindrome introduced in the yeast genome will affect its genetic stability. We studied the influence of palindrome size on recombination between two directly repeated copies of the yeast CYC1 gene leading to the loss of the intervening sequence ("pop-out" recombination).

Palindromic sequences; Genetic stability; Yeast; Saccharomyces cerevisiae; COM1/SAE2; Recombination

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