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Immunohistochemically detected high expression of matrix metalloproteinase-2 as predictor of poor prognosis in Duke's B colon cancer (CROSBI ID 151940)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Šundov, Željko ; Tomić, Snježana ; Vilović, Katarina ; Kunac, Nenad ; Kalebić, Marija ; Bezić, Joško Immunohistochemically detected high expression of matrix metalloproteinase-2 as predictor of poor prognosis in Duke's B colon cancer // Croatian medical journal, 49 (2008), 5; 636-642. doi: 10.3325/cmj.2008.5.636

Podaci o odgovornosti

Šundov, Željko ; Tomić, Snježana ; Vilović, Katarina ; Kunac, Nenad ; Kalebić, Marija ; Bezić, Joško

engleski

Immunohistochemically detected high expression of matrix metalloproteinase-2 as predictor of poor prognosis in Duke's B colon cancer

To demonstrate immunohistochemical expression of matrix metalloproteinase-2 (MMP-2) protein in Duke's B colon cancer and determine its correlation with age, sex, grade, presence of vascular invasion, and patients' overall survival. METHOD: The study took place from January 1995 to December 1997. We determined the expression of MMP-2 in 152 formalin-fixed, paraffin embedded specimens of Duke's B colon carcinomas by immunohistochemical analysis using MMP-2 monoclonal antibody. Immunohistochemical expression was scored semiquantitatively. Carcinomas were graded as low or high grade. Survival time was analyzed with Kaplan-Meier method, and the log-rank test was used to assess the differences between groups. Cox proportional hazard regression model was used for multivariate survival analysis. RESULT: Univariate analysis showed that positive staining for MMP-2, high histological grade, vascular invasion, male sex, and age>60 years were associated with shorter survival in patients with Duke's B colon cancer (P range from 0.023 to <0.001). Multivariate analysis showed that only MMP-2 overexpression (P<0.001 ; hazard ratio [HR]=3.64) and vascular invasion (P<0.001 ; HR=4.27) were associated with shorter overall survival. CONCLUSION: Expression of MMP-2 is an important independent indicator of shorter survival in patients with Duke's B colon cancer and should be taken into consideration in decision-making on the use of adjuvant systemic therapy in patients with Duke's B colon cancer.

colon cancer; immunohistochemistry; MMP-2

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Podaci o izdanju

49 (5)

2008.

636-642

objavljeno

0353-9504

10.3325/cmj.2008.5.636

Povezanost rada

Kliničke medicinske znanosti

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