The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects (CROSBI ID 152217)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pivac, Nela ; Nedić, Gordana ; Mustapić, Maja ; Babić, Ana ; Stipčević, Tamara ; Borovečki, Fran ; Hajnšek, Sanja ; Muck-Šeler, Dorotea
engleski
The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects
A polymorphism in the serotonin transporter gene (5-HTTLPR) is frequently studied for association with antidepressant treatment response, different personality traits, and psychiatric disorders. Baseline platelet serotonin (5-HT) concentration has been proposed to indicate a good or a poor treatment response to antidepressant drugs and to be associated with particular symptoms in psychiatric disorders. The aim of the study was to elucidate the genotype-phenotype relationship between platelet 5-HT concentration and 5-HTTLPR in healthy subjects. The frequency of 5-HTTLPR genotypes and alleles, as well as platelet 5-HT concentration were evaluated in 434 male and 86 female unrelated healthy medication-free Caucasian subjects of Croatian origin. A two-way ANOVA revealed no significant difference in platelet 5-HT concentration subdivided according to the particular 5-HTTLPR genotype, no significant effect of sex (F=0.122 ; d.f.=1, 514 ; P=0.727), no significant effect of genotype (F=1.000 ; d.f.=2, 514 ; P=0.369), and no significant interaction between sex and genotype (F=2.031 ; d.f.=2, 514 ; P=0.132) on platelet 5-HT concentration. In addition, one-way ANOVAs did not detect significant effects of homozygous S/S genotype (F=1.401 ; d.f.=3, 516 ; P=0.242), or homozygous L/L genotype (F=1.690 ; d.f.=3, 516 ; P=0.168) on platelet 5-HT concentration. Our results showed a lack of significant association between platelet 5-HT concentration and 5-HTTLPR variants, suggesting that there is no functional relationship between 5-HTTLPR alleles and platelet 5-HT concentration in the large groups of healthy control male and female medication-free Caucasian subjects, free of neuro-psychiatric disorders.
Healthy subjects ; Genetics ; Platelet serotonin concentration ; Serotonin transporter gene promoter polymorphism
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Podaci o izdanju
462 (1)
2009.
45-48
objavljeno
0304-3940
1872-7972
10.1016/j.neulet.2009.06.080
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti