Molecular Recognition Theory in Development of Vaccines (CROSBI ID 551078)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Štambuk, Nikola ; Konjevoda, Paško ; Pokrić, Biserka
engleski
Molecular Recognition Theory in Development of Vaccines
Molecular Recognition Theory (MRT) is based on the finding that peptides specified by the complementary RNAs and DNAs bind to each other with higher specificity and efficacy. It is an applicable heuristic algorithm for the identification of possibly interacting amino acid pairs of short linear epitope/paratope sites. The limitation of MRT is that it cannot explain 3D protein interactions, but it can be a valuable starting point for more complex computational and experimental analysis. In order to achieve better efficacy the heuristic algorithm of molecular recognition has to be combined to several other procedures: molecular hydropathy analyses, secondary structure prediction methods, and protein database search. Described concept represents useful and simple set of procedures for the modulation and investigation of targeted peptide– receptor, i.e., epitope– paratope interactions. It could also simplify experimental procedures, reduce the costs of the peptide synthesis, improve peptide structure modelling and identify possible targets relevant for the vaccine development and toxicology.
molecular ; recognition ; theory ; vaccine ; development ; toxicology
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Podaci o prilogu
78-78.
2009.
objavljeno
Podaci o matičnoj publikaciji
Graovac, Ante ; Pokrić, Biserka ; Smrečki, Vilko
Zagreb: Hum naklada
978-953-6954-51-3
Podaci o skupu
The 24th International Course & Conference MATH/CHEM/COMP
poster
08.06.2009-13.06.2009
Dubrovnik, Hrvatska