engleski

Bone morphogenetic proteins : From developmental signals to tissue regeneration

At present, bone is the only human organ that can be fully regenerated by exogenously applied bone morphogenetic proteins (BMPs) when physiological mechanisms of fracture repair fail. Since the identification of BMPs (Urist, 1965 ; Sampath & Reddi, 1981 ; Wozney et al, 1988 ; Ozkaynak et al, 1990 ; Chang et al, 1994), there have been many scientific discoveries and clinical reports on their use (reviewed by Vukicevic & Sampath, 2004). More than 340, 000 patients worldwide have been successfully treated with recombinant BMPs for long-bone non-unions, acute fractures and spinal fusions. At the Sixth International Conference on Bone Morphogenetic Proteins, the roles of BMPs in signal transduction, developmental biology, metabolic bone diseases, joint and cartilage repair, skeleton reconstruction, kidney regeneration and tumour biology were discussed by leading experts in the field.

bone morphogenetic proteins

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