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izvor podataka: crosbi

Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry (CROSBI ID 152640)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Grgurević, Lovorka ; Maček, Boris ; Đurđević, Dragan ; Vukičević, Slobodan Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry // International orthopaedics, 31 (2007), 743-751

Podaci o odgovornosti

Grgurević, Lovorka ; Maček, Boris ; Đurđević, Dragan ; Vukičević, Slobodan

engleski

Detection of bone and cartilage-related proteins in plasma of patients with a bone fracture using liquid chromatography-mass spectrometry

Following bone fracture, a large number of growth factors, cytokines, and their cognate receptors involved in the repair process are active at the fracture site. To determine whether they appear in patients' blood as candidate biomarkers for following the outcome of healing, we analysed the plasma of 25 patients with an acute bone fracture following affinity plasma purification, SDS gel electrophoresis and liquid chromatography - tandem mass spectrometry (LC-MS/MS). Two hundred and thirteen nonredundant proteins were identified in the in-gel analysis of pooled plasma proteins. Gene ontology (GO) analysis indicated that a majority of detected proteins were of extracellular origin, whereas only a small number were of intracellular (cytosol and nucleus) origin. A significant proportion of detected proteins was involved in the cell growth and proliferation, transport and coagulation. Twelve proteins were potentially related to bone and cartilage metabolism, and several have not been previously identified in the plasma, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor II

bone morphogenetic proteins; plasma; bone fracture; LC-MS

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Podaci o izdanju

31

2007.

743-751

objavljeno

0341-2695

Povezanost rada

nije evidentirano

Indeksiranost