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Neurotransmitori u simpatikusu (CROSBI ID 86652)

Prilog u časopisu | stručni rad

Zorc, Branka ; Knežević, Natalija Neurotransmitori u simpatikusu // Farmaceutski glasnik, 56 (2000), 12; 429-436-x

Podaci o odgovornosti

Zorc, Branka ; Knežević, Natalija

hrvatski

Neurotransmitori u simpatikusu

Noradrenaline (norepinephrine) and adrenaline (epinephrine) are direct-acting sympathomimetics. Their pharmacological effects are similar, but not identical. Noradrenaline has stronger interaction with a- and b1-receptors and adrenaline interacts similarly with all adrenergic receptors. Noradrenaline causes general vasocontriction with the exception of coronary arteries and, hence, increases systolic and diastolic blood pressure. It is used to provide haemodynamic support in various cardiovascular disorders. Adrenaline contracts blood vessels in the skin, mucosa and visceral tissues, but dilates blood vessels of the skeletal muscles and heart when given in low doses within the physiological range. It relaxes intestinal and bronchial muscle and has positive inotropic and chronotropic actions on the heart. Adrenaline has an important role in the management of acute allergic reactions and can be life saving in patients with anaphylactic shock. It is also used in advanced cardiac life support, for controling of minor bleeding, in ophtalmology as a mydriatic and for the management of certain type of glaucoma. It is frequently added to local anaesthetics to prolong the duration of effect and to lessen the toxicity. Dopamine is a neurotransmitter in the brain and a precursor of noradrenaline. It is both a direct- and indirect-acting sympathomimetic agent. It is employed for its inotropic effect. In the treatment of parkinsonism its precursor levodopa is used.

neurotransmitor; simpatikus; adrenalin; noradrenalin; dopamin

nije evidentirano

engleski

Neurotransmitters in sympathetic system

nije evidentirano

neurotransmitter; sympathetic system; adrenaline; noradrenaline; dopamine

nije evidentirano

Podaci o izdanju

56 (12)

2000.

429-436-x

objavljeno

0014-8202

Povezanost rada

Kemija

Indeksiranost