engleski

Cerebrovascular disease and diabetes mellitus

Stroke is the third most frequent cause of death worldwide and the most frequent cause of permanent disability. Of patients who suffered stroke, a large proportion either has or is later diagnosed with diabetes (16-24%). Patients with diabetes are at 1.5-3 times the risk of stroke compared with general population and associated mortality and morbidity is greater than in those without this underlying condition. Even patients with metabolic sindrome component have a 1.5 fold increased risk of stroke. This is primarily due to increased proatherogenic risk factors-abnormal plasma lipid profiles, hypertension, hyperglycaemia. However, other pathological features associated with diabetes, such as insulin resistance and hyperinsulinaemia, also lead to atherosclerotic changes in extracranial and intracranial vessels independetly of glycaemia or other attendant risk factors. This is particularly expressed in smller cerebral vessels increasing the incidence of both- overt and silent lacunar infarctions...

diabetes; stroke; cerebrovascular disease

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