engleski

The incidence of positive family hystory for atopic disease in children having allergic and non-allergic asthma

Atopy and asthma are realted conditions, involving and interplay of environmental and genetic factors. Numerous loci and candidate genes have been reported to show linkage and association with asthma and asthma-associated fenotypes, atopy, elevated IgE levels and bronchial hyperesponsivess. Our aim was to acquaire information about the occurence of asthma, pollinosis and other allergic conditions in children having bronchoobstructions. Positive family history of asthma and/or pollinosis was obtained for 58.9% o children having allergic asthma compared with 35.7% of children having non-allergic asthma. On the other hand, positive family history for various atopic manifestations was obtained for 77 and 73.6% respective children. Positive family history for atopic disease, in particular from mothers side represents significant risk factor for allergic asthma in children.

asthma; children; positive family history for atopic disease

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