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Lipid modifications by free radicals: Peroxidation vs. Isomerization (CROSBI ID 553451)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Tartaro, Ivana ; Mihaljević, Branka Lipid modifications by free radicals: Peroxidation vs. Isomerization // European Young Investigator Conference, Slubice, Poland, 2009. 2009. str. 30-x

Podaci o odgovornosti

Tartaro, Ivana ; Mihaljević, Branka

engleski

Lipid modifications by free radicals: Peroxidation vs. Isomerization

During oxidative stress reactive oxygen species and peroxyl radicals of lipids can be scavenged by good hydrogen donors such as thiols, leading to interrupting the cascade of the lipid peroxidation process. Therefore thiols are considered to be effective protectors for the lipid degradation under oxidative conditions. On the other side, thiyl radicals generated from thiols by free radicals cause the isomerization of the double bonds, with the formation of geometrical lipid trans isomers.The general objective of this work was a comparative study of the behaviour of unsaturated fatty acid in the presence of thiols. Primary radicals were generated by γ -irradiation of a model lipid system containing linoleic acid (LiH), nonionic surfactant (Tween 20) and 2-mercaptoethanol at pH 5. After γ -irradiation of the model systems up to 400 Gy and in the presence of oxygen, high concentration of LiOOH (1 × 10– 4 mol dm-3) was determined, while the amount of trans LiH methyl ester simultaneously formed under the same conditions was very low (~ 10 %). However, in the absence of oxygen the effective inhibition of propagation of lipid peroxidation with subsequent increasing of the isomerization processes was observed. It was found that the amount of trans isomers increased with increasing of the irradiation dose. The effect of the dose rate on the lipid modification processes was also investigated.

gamma irradiation; lipid peroxidation; isomerization; micelle

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Podaci o prilogu

30-x.

2009.

objavljeno

Podaci o matičnoj publikaciji

European Young Investigator Conference, Slubice, Poland, 2009

Podaci o skupu

4th European Young Investigator Conference 2009

predavanje

18.06.2009-21.06.2009

Słubice, Poljska

Povezanost rada

Kemija