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The effect of chloramphenicol on hepatic biotransformation enzyme activity and on the duration of pentobarbital or ketamine/xylazine anesthesia in guinea pigs (Cavia porcellus) (CROSBI ID 154397)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Prevendar Crnić, Andreja ; Pompe-Gotal, Jelena ; Božić, Frane ; Šuran, Jelena ; Velev, Romel ; Sakar, Darko The effect of chloramphenicol on hepatic biotransformation enzyme activity and on the duration of pentobarbital or ketamine/xylazine anesthesia in guinea pigs (Cavia porcellus) // Veterinarski arhiv, 79 (2009), 4; 385-396

Podaci o odgovornosti

Prevendar Crnić, Andreja ; Pompe-Gotal, Jelena ; Božić, Frane ; Šuran, Jelena ; Velev, Romel ; Sakar, Darko

engleski

The effect of chloramphenicol on hepatic biotransformation enzyme activity and on the duration of pentobarbital or ketamine/xylazine anesthesia in guinea pigs (Cavia porcellus)

The effect was investigated of chloramphenicol on activities of hepatic biotransformation enzymes: aniline hydroxylase (Ah) and ethylmorphine N- demethylase (EtND), as well as on the levels of serum alanine aminotransferase (ALT) and glutamate dehydrogenase (GLDH) in guinea pigs (Cavia porcellus). Moreover, the influence was established of the pre-medication with chloramphenicol on the duration of anesthesia using pentobarbital and ketamine/xylazine guinea pigs. Male guinea pigs, weighing 269-353 g, were subcutanely (s.c.) treated with 60- and 100 mg chloramphenicol sodium succinate/kg body weight once a day for three days. Thereafter the anestetics were injected: 30 mg pentobarbital/kg b.w., i.p. in one group and 60 mg ketamine/kg b.w., s.c. + 4 mg xylazine/kg b.w., s.c. in the other group. Treatment with chloramphenicol did not significantly affect the concentration of serum ALT or GLDH. As expected, 100 mg chloramphenicol/kg b.w. significantly decreased the activity of Ah and EtND for -36.1% and -38.6%, respectively. On the other hand, the duration of pentobarbital anesthesia and ketamine/xylazine- induced anesthesia in chloramphenicol pretreated animals was not significantly prolonged. Our results also indicate that decreased enzymes activity in presence of chloramphenicol did not influence the hepatic metabolism of two tested anesthetics in guinea pigs, and in contrast to dogs, cats, rats and mice, did not prolong the duration of anesthesia.

chloramphenicol ; pentobarbital ; ketamine/xylazine ; biotransformation ; alanine aminotransferase ; glutamate dehydrogenase ; guinea pig ; Cavia porcellus

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Podaci o izdanju

79 (4)

2009.

385-396

objavljeno

0372-5480

1331-8055

Povezanost rada

Veterinarska medicina

Indeksiranost