engleski

Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic beta-cells

Uric acid (1a) suppresses basal insulin in isolated rat pancreatic islets and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (greater than or equal to 0.4mM). Conversely, 1mMquanidinium urate (2a) was completely ineffective, strongly suggesting that binding to an essential arginine residue triggers the inhibitory effect. A specific recognition of 2a molecule at the crucial beta-cell receptor is probably involved in the blocking glucose signal transduction.

uric acid; quanidinium urate; glucose-stimulated insulin secretion; arginine; inhibition; pancreatic islets

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