engleski

Pharmacologic Effects of Cocoa and Rye Flour Extracts on Isolated Guinea Pig Trachea

The effects of cocoa and rye flour extract on isolated guinea pig tracheal smouth muscle were studied.Dose-related contractions of nonsensitizited guinea pig tracheal rings were demonstrated.Constrictor effetcs of the dust extracts were inhibited by different pharmacologic agents.These observations suggest a relase of parasympathetic mediators by these extarcts or more dirrectly an interaction with muscarinic receptors.Data suggest that cocoa and rye flour extract cause a doe- related constriction of airway smooth muscle by non immulogical mechanisms involving cholinergic pathways airway mediators such as histamine and the product of the arachidonic acid cascade.

Cocoa extract;Rye flour extract;Isolated guinea pig trachea

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