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Clinical manifestations of neurosarcoidosis

Sarcoidosis is a chronic disease of unknown aetiology. Neurosarcoidosis is registered in 5% of patients with sarcoidosis. Clinical manifestations of sarcoidosis are numerous and diverse. Manifestation of neurosarcoidosis includes partial- and grand-mal seizures, low-grade fever, headache, increased intracranial pressure, visual disturbance, diabetes insipidus, amenorrheea-galactororrha syndrome and pituitary failure, hypogonadotropic hypogonadism, hyperprolactinemia, unilateral and bilateral facial palsy, infiltration of meninges (aseptic meningitis) and nerve roots, leptomeningitis, pachymeningitis with cranial neuropathies, pseudotumor, mild cognitive disorder, psychosis, delirum, dementia, disorienttation, amnesia, progressive visual deterioration and proptosis, axonal polyneuropathies, mononeuropathies, chronic polyraediculoneuritis, peripheral neuropathy, cranial nerve abnormalities, radiculopathies, peripheral neuropathy, mononeuritis multiplex, progressive numbness and deep sensation disturbance in bilateral lower extremities, hemiplegia, hyperreflekxia with pathological reflexes and hypesthesia, upward gaze palsy, spinal cord compression, dysarthria, dyshhagia, weakness, episodes of blurred vision, diplopia, intracranial hemorrhage, neuro-ophthalmic manifestations, intranuclear ophthalmoplegia, dysorientation, vasculitis presenting with strokes, intracranial hypothalamic lesion, paresthesis, hemiparesis, myelopathy in the cervico-thoracic region, lumbal pain, sensory level and inability of lateral gaze.

sarcoidosis ; neurosarcoidosis ; hydrocephalus and intracranial hemorrhage

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